This chapter contains an overview of engagement, adherence, and retention strategies in the context of empirically supported treatment for panic disorder from both a research and clinical lens. First, a description of panic disorder (PD) is presented. Next, the etiology and development are described, followed by an explanation of panic disorder from a cognitive behavioral therapy model. Diagnosis and assessment of panic disorder are explained. Treatment options for panic disorder are described, with a focus on the efficacy of cognitive behavioral therapy. Issues of treatment engagement, retention, and barriers to care are also discussed, and potential solutions are provided. Next, two clinical case vignettes are provided to give readers examples of different clinical components that warrant important additional treatment considerations prior to beginning CBT for PD. These vignettes offer descriptions of clinical planning, psychoeducation, cognitive restructuring, and interoceptive exposures. Finally, future directions for panic disorder treatment research are presented, focusing on digital mental health interventions to improve engagement.