This chapter explores the transformative potential of Web3 within Decentralized Science (DeSci), an emerging movement and concept expected to revolutionize science. Leveraging Distributed Ledger Technology (DLT) and inherent capabilities such as smart contracts, Decentralized Autonomous Organizations (DAOs) and governance tokens, DeSci aims to address some of the longstanding challenges of modern science such as funding acquisition, collaboration efficiency, and transparent ownership. Given the novelty of DeSci and Web3, important challenges and limitations need to be considered. These challenges include technological limitations, ethical concerns and governance issues. To address these challenges, this chapter presents a series of recommendations for the advancement of DeSci. These recommendations emphasize the establishment of robust educational frameworks to enhance Web3 and DeSci literacy, the formulation of comprehensive governance models to guide ethical decision-making, and the implementation of best practices to ensure technological efficiency and integrity within the DeSci ecosystem.