Scholarlink

The purpose of this study is to establish the variation in inspiratory pressure throughout pressure-controlled mechanical ventilation, with regard to the partial pressures of carbon dioxide (PACO2) and dioxygen (PAO2) inside a Simulink model that characterizes five pediatric age groups: 4 months, 1 year, 2 years, 4 years, and 6 years, through the use of Endotracheal Tube (ETT) diameters respectively from 3.5 to 5.5 mm. The model included nonlinear resistance of the ETTs and inspiratory pressures from 8 to 12 cmH₂O with a constant PEEP of 5 cmH₂O. The results indicated that changes in inspiratory pressure (IP) affected significantly both PACO2 and PAO2 levels. For instance, in a 4-month-old with a respiratory system resistance (Rrs) of 40 cmH2O/L/s, a respiratory system compliance (Crs) of 3 mL/cmH2O, a respiratory frequency of 30 breaths/min, an inspiratory to expiratory time ratio (Ti/Te) of 1:2 and a 3.5 mm ETT, the PACO2 fell from 47.86 mmHg to 36.62 mmHg, while the PAO2 increased from 77.21 mmHg to 94.25 mmHg when IP increased from 8 cmH₂O to 12 cmH₂O. It also points out the possible development of algorithms that, automatically, may change settings of pressure-controlled ventilation according to individual respiratory mechanics and ETT characteristics for the optimization of ventilation and oxygenation, minimizing risks of barotrauma and safely weaning from mechanical support.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of Respiratory Mechanics, Endotracheal Tube and Ventilator Parameters on Pediatric Gas Exchange During Pressure Controlled Mechanical Ventilation: Simulation Study

  • 会议论文

  • 发表日期：

    2025年

查看全文
  • Mohamed Bourti,
  • Abdelaziz Belaguid

摘要

The purpose of this study is to establish the variation in inspiratory pressure throughout pressure-controlled mechanical ventilation, with regard to the partial pressures of carbon dioxide (PACO2) and dioxygen (PAO2) inside a Simulink model that characterizes five pediatric age groups: 4 months, 1 year, 2 years, 4 years, and 6 years, through the use of Endotracheal Tube (ETT) diameters respectively from 3.5 to 5.5 mm. The model included nonlinear resistance of the ETTs and inspiratory pressures from 8 to 12 cmH₂O with a constant PEEP of 5 cmH₂O. The results indicated that changes in inspiratory pressure (IP) affected significantly both PACO2 and PAO2 levels. For instance, in a 4-month-old with a respiratory system resistance (Rrs) of 40 cmH2O/L/s, a respiratory system compliance (Crs) of 3 mL/cmH2O, a respiratory frequency of 30 breaths/min, an inspiratory to expiratory time ratio (Ti/Te) of 1:2 and a 3.5 mm ETT, the PACO2 fell from 47.86 mmHg to 36.62 mmHg, while the PAO2 increased from 77.21 mmHg to 94.25 mmHg when IP increased from 8 cmH₂O to 12 cmH₂O. It also points out the possible development of algorithms that, automatically, may change settings of pressure-controlled ventilation according to individual respiratory mechanics and ETT characteristics for the optimization of ventilation and oxygenation, minimizing risks of barotrauma and safely weaning from mechanical support.