Neuro disabilities are physical conditions characterized by intellectual impairments, impairments in adaptive functioning, and onset before the age of 18. These impairments represent a substantial limitation in the individual’s life and will require cognitive-based treatment approaches involving high specialization. Worth noting, the interest in strategies for early recognition of these disorders has dramatically increased as they are increasingly recognized as a health, economic, and social issue. As a matter of fact, early diagnostic interventions are expected to have an important impact on several outcomes, as they reduce suffering, symptom severity, and functional impairment, along with comorbid conditions. A tripling of the global prevalence compared to their healthy peers can be surmised, leading to major economic and social costs. Society is also challenged by neuro disabilities, mental healthcare, and public outcomes, and services often offer non-integrated responses to these disorders and, therefore, do not account for their “great imitators” nature. A comprehensive approach that integrates both medical and social disciplines, along with relative facilities and operators, should be considered. Early diagnosis is an essential starting point for this integrated response and requires interdisciplinary in the healthcare and medical fields, as demonstrated. A substantial number of individuals with neuro-disability can experience a great deal of delay or even miss their prevalence in the clinical and rehabilitative approaches tailored to their needs. The purpose is to make practitioners, healthcare staff, and researchers accountable for treating, assisting, and searching for methods of early diagnosis in neuro disabilities.