In the United States, around 1.7 million people reside in long-term care facilities, which accounts for 25% of annual deaths. The need for hospice and palliative care is rapidly increasing due to an aging population, longer life expectancies, and a rise in chronic diseases. Palliative care emerged from the hospice movement to address the needs of patients with serious illnesses, regardless of their prognosis and encompasses a range of services aimed at improving the quality of life for both the patient and their family. It focuses on holistic support—psychological, social, physical, spiritual, pain management, symptom relief, and emotional and spiritual well-being—across various stages of illness. This integrative approach enhances the quality of life and is provided by an interdisciplinary team in various settings, including homes, communities, outpatient centers like pain and symptom management clinics, community living centers, and inpatient facilities. This chapter distinguishes between palliative and hospice care and describes the benefits of palliative care, models of care across long-term care settings, cross-cultural perspectives, and ethical and legal considerations.