Person-centered care in long-term care (LTC) is an individualized approach in which care partners tailor their support to meet the unique needs and overall well-being of the care recipient, encompassing their physical, mental, and social health. However, realizing the full potential of person-centered care necessitates a transformative shift in LTC culture and practices to ensure high-quality care for all residents, particularly those with dementia. Despite the importance of this transformation, efforts to modify individual behaviors and organizational practices often face significant barriers, leading to a tendency to revert to traditional methods. This chapter explores diverse perspectives on the well-being of residents, both with and without dementia, and connects these insights to the core principles of person-centered care. It will examine the barriers and facilitators that influence the culture change movement and stress the urgency for collaboration among residents, families, staff, and other partners in enhancing residents’ quality of life. For the successful implementation of person-centered care, it is essential that every member of the care team engages holistically in health equity and health promotion strategies, fostering an environment that prioritizes the care and well-being of all residents in LTC.