The skin, which is the body’s largest organ, plays a crucial role in protecting the body from external influences. In addition, the skin contributes to the prevention of fluid loss, thermoregulation, immune surveillance, and sensory perception. Impairment of the integrity and functionality of skin tissue, whether due to mechanical forces, surgical procedures, burns (chemical, electrical, or radiation), frostbite, genetic disorders (such as epidermolysis bullosa), or ulcers from chronic conditions, has a profound impact on the patient’s quality of life and may even lead to death. Chronic wounds, particularly those associated with diabetes mellitus, represent a significant health burden, with a considerable economic and social impact on the patient. Therefore, understanding the fundamental mechanisms of wound healing is crucial for selecting an appropriate wound dressing and developing an effective treatment plan. This section will present information regarding the development of hydrogels for use in wound healing. Prior to addressing this topic, it would be beneficial to discuss the structure and functions of the skin, as well as the mechanisms of wound healing, to gain a deeper understanding of the subject.