This research therefore aims at exploring the social and political interactions between Jews tribes in Medina and the emerging Muslim society at the time of the prophet Muhammad especially after the Hijra. Using historical analysis and employing AI methods, the work gives a detailed picture of the causes, including tribal affiliations, economic motives, and political connections, that shaped the relationships and tensions between the Jewish tribes, including Banu Qaynuqa, Banu Nadir, and Banu Qurayza. In fact, the Constitution of Medina, which was designed to help the community unite, later turned into a subject of discussion of the relations between the Muslim and other peoples as well as the strategies of governance, which gradually began to unravel due to tensions. AI tools added value in that they allowed for the identification of changes in sentiment and relationships between particular events, which would not have been possible by other means. Thus, the work not only enriches Islamic historical narrative but also points to the possible role of AI in historical analysis and future development of the digital humanities. The results underscore the potential of using AI methodologies alongside historical analysis to enrich analytical depth; however, the study’s limitations are the interpretative bias and data quality issues. Further studies are recommended to develop the AI applications in the historical environment, perhaps expanding this method to the other areas of Islamic history to enrich both research and educational processes.