Biomedical implants have undergone a revolution with the introduction of additive manufacturing (AM), which offers previously unheard-of levels of precision and customization. This chapter explores the biocompatibility of metal implants made by additive manufacturing, which is essential to their effective integration and operation in the human body. We scrutinize various metals, including titanium alloys, cobalt-chromium alloys, and stainless steel, commonly used in additive manufacturing for implants, focusing on their mechanical and biological properties. The chapter explores the complex interplay between AM implants surfaces and biological tissues, highlighting the significance of surface modification methods to improve biocompatibility. We also discuss the hazards and obstacles that may arise from AM metal implants, such as corrosion, inflammatory reactions, and metal ion leakage. This chapter attempts to provide a complete overview of the current developments and future prospects in the field of biocompatible, additively produced metal implants through a thorough assessment of recent studies and clinical applications.