In this chapter I introduce and contextualize Promethean posthumanism, pointing out its contrasts with transhumanism and resonances with other philosophical orientations, such as Bernard Stiegler’s phenomenological pharmacology of technology. I identify the political or ethical heart of Prometheanism as a rejection of any “given” limits to the (post)human. Rather than seeing ethical or political limits as given, Prometheans are committed to the construction of rational technologies—indeed, of reason as a technology—that can provide us with normative guidance. I suggest that this may in fact lead to a profound normative disorientation (though I do not defend any philosophy of the given, and in later chapters will suggest that profound normative disorientation is our lot).