In this first chapter I introduce the basic aims of the text, before exploring the thermodynamic and informational themes of Asimov’s “The Last Question.” Accelerationism and Prometheanism have always been informed by the tropes of science fiction, and I argue here that the themes of reducing entropy and the transcendence of artificial intelligence, with their roots in the fledgling post-war science of cybernetics, inform both of these posthuman projects. I discuss the statistical mechanical interpretation of the Second Law of thermodynamics, and its connections to information theory, as well as Maxwell’s Demon, taking some time to emphasize that classical Shannon information is a non-semantic measure of probability.