The knowledge of the reaction rateReaction rate equationRate equations frequently allows the researcher to draw deductive conclusions on theReaction mechanisms reaction mechanism. However, it does not usually provide practical information on the nature of the reactive forms of the species participating in the reaction. Very often, the knowledge of the reaction rateReaction rate equationRate equations or the reaction orderReaction order of individual species involved in the reaction may not be sufficient for drawing conclusions on the character and/or composition of the transition state and several possibilities remain, and making a choice to become a simple guess. The researcher must use deductive reasoning rather than guessing, and for the purpose further information needs to be obtained to lay a solid scientific ground supporting the eventual hypothesis that can be put forward. This information can be obtained from the analysis of the effects of varying the composition of the reaction mixture on the reaction ratesReaction rate, and will be—certainly—crucial in the deduction—eliminating process to finally achieve the most probable reactionMechanisms mechanism consistent with experimental observations. Particularly, the analyses of theEffects of acidity effects of acidityAcidity, solventSolvent, ionic strength,Ionic strength and temperatureTemperature on the values of the rate constantsRate constant offer diagnostic tools providing a valuable and essential opportunity to discern between various potentialReaction mechanisms reaction mechanismsMechanisms. Researchers, therefore, can make deductions on the reactionMechanisms mechanism from the knowledge of the nature and properties of the starting materials, products, and on the overall equation for the reaction rateReaction rate. The aim of this chapter is, therefore, an attempt of showing the reader how to use deductive reasoning from variations in the observed rate constantRate constant upon changing the solution composition to finally propose a reasonableReaction mechanisms reaction mechanism.