This study evaluates the seismic response of reinforced concrete frame structures with masonry infill walls through advanced analytical and numerical modeling. Utilizing software such as STKO and OpenSees, the study replicates shake table tests to gain a detailed understanding of hysteretic energy dissipation across various structural components. The structure demonstrated significant consistency between experimental and analytical data, particularly in the initial loading phases. The analyses reveal that masonry infills contribute substantially to overall energy dissipation, crucial for reaching key damage states. Detailed examination of concrete and steel behavior indicates that while concrete significantly contributes to energy dissipation, steel remains largely elastic, contributing less to overall damage. A critical finding is the chaotic response behavior of the central column on the first level, attributed to confinement and interactions with surrounding elements. The new methodology focusing on identifying major response variations proves effective, showing coherent results with experimental evidence and enabling multiscale analysis. This approach allows for precise identification of damage states by analyzing energy jumps and intensity variations, crucial for predicting structural behavior under progressive loading and fatigue conditions. The results indicate that the new method provides insights that would be unattainable through traditional energy hysteresis or hysteresis loop backbone analysis alone, validating its application in seismic design and structural assessment.