Bone growth requires a coordination of processes to lengthen the mineralized matrix. This activity is centralized at the growth plate and involves both cartilage and bone cells. Bone modeling and remodeling, while sharing some similar features, are uniquely different processes. Bone modeling plays an important role during growth and serves mainly to reshape and grow bones. Bone remodeling occurs throughout life and serves a main function of renewing/replacing bone tissue. The process of bone remodeling is complex, can be estimated through bone histomorphometry, and can be modeled through mathematical calculations. Such calculations provide a means of hypothesis generation to assess/understand the physiologically complex nature of remodeling. Bone modeling and remodeling play a fundamental role in fracture healing, which integrates both physiological processes on an accelerated timeframe.