The vulnerability of LGBTIQ+ persons is accelerated by the intersecting forms of discrimination they face in multiple and overlapping ways. A constellation of factors increases the vulnerability of intersex persons and non-binary and gender-diverse persons. With limited visibility, they have been subjected to historical discrimination in varying contexts (legal, policy, social, cultural, political, workplace, etc.). Recent case law before the European Court of Human Rights and the Court of Justice of the European Union opens up the space for interaction with the lived experiences of these two groups and critical thinking on the interpretation of human rights law in Europe.