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The exploration of molecular hydrogen (H2) as a therapeutic agent for reducing oxidative stress in cardiovascular disorders (CVD) has gained a substantial attention in recent decades. H2 serves as an upstream signaling molecule for carbon monoxide (CO) and interacts with oxidized iron porphyrins, particularly hematin, to alleviate oxidative stress in different pathological situations including postischemic heart stunning, myocardial lethal injury and occurrence of malignant tachyarrhythmias. However, its role in the mechanisms of CVD, as well as in the protection against CV disorders remains not completely understood and requires further elucidation.

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The Effect of Molecular Hydrogen on the Mitigation of Oxidative Stress in Cardiovascular Disorders

  • 章节

  • 发表日期：

    2025年

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  • Ján Slezák,
  • Tatiana Ravingerova,
  • Branislav Kura

摘要

The exploration of molecular hydrogen (H2) as a therapeutic agent for reducing oxidative stress in cardiovascular disorders (CVD) has gained a substantial attention in recent decades. H2 serves as an upstream signaling molecule for carbon monoxide (CO) and interacts with oxidized iron porphyrins, particularly hematin, to alleviate oxidative stress in different pathological situations including postischemic heart stunning, myocardial lethal injury and occurrence of malignant tachyarrhythmias. However, its role in the mechanisms of CVD, as well as in the protection against CV disorders remains not completely understood and requires further elucidation.