The phospholipid membrane is one of biology’s most pervasive structures and represents an ideal scaffold for a host of nanotechnology applications. Whether as a vehicle for the biological engineering of biomimetic technologies or for designing therapies to interface with the cell, a phospholipid membrane can provide the necessary molecular-level control of membrane-anchored proteins, glycopeptides, and glycolipids applications [1]. An elegant published example of a lipid membrane structure that illustrates this concept is the incorporation of two proteins that have a combined function to produce ATP [2]. This structure includes the proteins bacteriorhodopsin and the F0F1-ATPase complex. The structure is illustrated in Fig. 4.1.

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Where Does Biomimetic Membrane Technology Fit into Biological Engineering?

  • Donald Martin,
  • Isabelle Vilgrain

摘要

The phospholipid membrane is one of biology’s most pervasive structures and represents an ideal scaffold for a host of nanotechnology applications. Whether as a vehicle for the biological engineering of biomimetic technologies or for designing therapies to interface with the cell, a phospholipid membrane can provide the necessary molecular-level control of membrane-anchored proteins, glycopeptides, and glycolipids applications [1]. An elegant published example of a lipid membrane structure that illustrates this concept is the incorporation of two proteins that have a combined function to produce ATP [2]. This structure includes the proteins bacteriorhodopsin and the F0F1-ATPase complex. The structure is illustrated in Fig. 4.1.