This chapter describes the commonly used MRI pulse sequences and techniques in neuroimaging at existing clinical magnetic field strengths of 1.5 and 3 Tesla. A review of spin-echo, fast-spin-echo, and gradient-recalled-echo pulse sequences will be discussed, along with their common clinical applications to T1-weighted, T2-weighted, and T2*-weighted brain and spine imaging. Additional useful techniques include inversion recovery magnetization preparation, diffusion-weighted imaging, and perfusion imaging using noncontrast arterial spin labeling. Advanced concepts, including functional MRI and susceptibility-weighted MRI, are briefly discussed. While much of the chapter is presented in the context of Cartesian rectilinear k-space MRI, an introduction to non-Cartesian MRI and potential benefits is also included. We highlight the key features of each pulse sequence and practical applications in neuroimaging.