This chapter investigates the process of interaction between the role and degree of influence of the human factor on ergonomic control systems in transport. The human factor, its components in the process of management in water transport systems, and the impact of technical systems on human activity are analyzed. The main focus is on studying the role and relationship between the human factor and ergatic control systems, such as automated systems, intelligent transport systems and other technological solutions used in water transport. The article is based on an analysis of scientific research, including psychological, sociological, and engineering aspects of the interaction between humans and ergonomic control systems. The main factors of human influence on ergatic systems are identified and evaluated. The analysis also makes it possible to understand how technical innovations affect the role of the human factor in the transport sector. The novelty of this article lies in the combination of the study of the impact of the human factor on the ergatic control systems in transport and the analysis of various aspects of this interaction. The material presented has a significant practical contribution, as it provides important recommendations for improving the process of interaction between the human factor and ergonomic control systems in transport.