Certain oral lesions exhibit an association with psychological or emotional factors, suggesting a connection between mental well-being and oral health. In contrast to solely attributing their origins to physical or biological factors, these lesions are believed to arise from or be exacerbated by psychological and emotional elements. It’s important to clarify that the term ‘psychogenic’ signifies a connection between the mind and the manifestation of oral symptoms, rather than implying the disease is imaginary or unreal. Emotional and psychological factors can serve as significant risk factors in the initiation and progression of oral mucosal diseases, with common culprits including stress, anxiety and depression. This chapter emphasises key aspects of psychogenic diseases affecting the oral cavity.