Cleft lip and palate (CLP) are congenital conditions that affect the formation of the upper lip and/or the roof of the mouth during foetal development. Cleft lip and palate occur when there is incomplete fusion of the lip and/or palate during foetal development. CLP are often referred to collectively as orofacial clefts and are usually associated with incomplete fusion of facial structures. Individuals with CLP may experience problems with feeding, speaking, hearing and social integration that can be corrected to varying degrees by surgery, dental treatment, speech therapy and psychosocial intervention. Management of these cases implies the need for a multidisciplinary team, laying the foundations of comprehensive rehabilitation. Although many disruptions are affecting the craniofacial complex, the overwhelming majority involve only the upper lip and/or palate. Approximately 70% of cases of CLP occur as isolated entities with no other apparent cognitive or craniofacial structural abnormalities; this is commonly termed isolated, non-syndromic CLP. Cleft lip and palate may be associated with some syndromes, most commonly the Van der Woude Syndrome.