The first case of COVID-19COVID-19 in NepalNepal was reported on January 23, 2020. Nation-wide lockdownsLockdown were imposed in March 2020 to curb the spread and prevent the morbidityMorbidity and mortalityMortality due to pandemicPandemic. Among total deaths due to COVID-19COVID-19 in NepalNepal, three times more deaths occurred in the second wave as compared to the first wave. Males, aged 60 years or older, patients from hills and patients with at least one comorbid condition were associated with a higher mortality. The GovernmentGovernment of NepalNepal took several measures for the preventionPrevention and control of COVID-19 and provided support to vulnerable groups. The High-Level Coordination Committee for COVID-19COVID-19 PreventionPrevention and Control coordinated the responseResponse and provide necessary policy directions. The COVID-19 Crisis Management Centre monitored the essential supplies, and conducted other necessary activities for preventionPrevention and control of COVID-19. NepalNepal started COVID-19COVID-19 vaccinationVaccination in early 2021. The coordinated responseResponse activities resulted in a relatively a smaller number of mortalities due to COVID-19 in NepalNepal. Taking lessons from COVID-19COVID-19, there are several policyResponse responsesPolicy response and activities to address pandemicsPandemic in the future. This chapter aims to summarize epidemiologyEpidemiology of COVID-19 and PolicyResponse ResponsePolicy response including, post-COVID-19 health situation in NepalNepal.