The Liver Imaging Reporting And Data System (LI-RADS) provides a comprehensive and integrated approach to diagnosing hepatocellular carcinoma (HCC) in at-risk patients. The system offers numerous advantages. It provides accurate diagnosis of HCC. It provides reliable diagnostic features and rigorous criteria. It provides standardized and precisely defined terminology. It is based on best available evidence and has been extensively investigated. It provides a granular, probabilistic approach that permits individualized management. It enables differentiation of HCC from other malignancies. It guides the entire spectrum of HCC imaging from surveillance to treatment response assessment. For these and other reasons, the authors conclude: Yes—all liver lesions in patients with cirrhosis undergoing hepatocellular carcinoma surveillance should be characterized and reported using LI-RADS criteria.