Using automation and digital technologies, Industry 4.0 has significantly boosted productivity and efficiency in the production and supply chain processes over the last few years. However, despite remarkable economic advantages, excessive automation and digitalization have proven to cause several social-economic issues, such as concerns over replacing human operators and potential environmental challenges. The 5th Industrial Revolution, which is still emerging, aims to tackle these challenges by complementing the existing Industry 4.0 approach and redefining the role and contribution of industry to society. It also aims to re-evaluate how machines and humans can collaborate to create more value in an industrial setting. Grounded on the existing literature on Industry 5.0 and supply chain management, this chapter presents a conceptual framework to guide how supply chain design and operations can be aligned with the aims and requirements of Industry 5.0. This framework defines the primary dimensions and essential pillars of Supply Chain 5.0, as well as key enabling technologies for the transition towards Supply Chain 5.0. The chapter further discusses how this newly emerged concept relates to the existing concepts in the supply chain literature, the potential challenges companies may face, and accordingly, some primary research directions towards tackling those challenges.