Osteogenesis imperfecta (OI) is a congenital bone disorder. The prominent clinical feature of OI is that the long bones are easily fractured, broken bones many times, bone deformity, and most patients cannot walk but mainly lie or sit in one place. To diagnose and classify OI, according to author Sillence (1979), X-ray is a test to detect bone abnormalities in patients with OI. Prospective study on 42 patients with OI at Military Hospital 7A - Military Region 7, from January 2012 to December 2016. The patient was examined by X-ray (anteroposterior and lateral position) in the following positions: skull, long bones of the upper and lower limbs, and spine. On X-ray, the long bones of the upper limbs have bone deformity, accounting for 19.0 - 21.4%; X-ray films of femurs with bone deformity account for 71.4 - 83.3% with 4 cases having the image of “popcorn calcification” and 4 cases of dense metaphyseal lines in the onion bones; X-ray images of tibia with bone deformity account for 61.9 - 64.3% and there were 2 cases with dense metaphyseal lines. Cranial X-rays were found in 7/42 cases with images of multiple wormian bones. X-ray of the spine showed 16/42 cases of scoliosis, 1 case of collapsed lumbar vertebrae. Research on X-ray characteristics in this study group of patients with OI shows that: Common X-ray films are multiple fontanelles, scoliosis, changes in long bones such as bone deformity, thinning of the cortical bone, old fractures on lower limb bones. The study provides some imaging characteristics of osteogenesis imperfecta. In the future, the data from the study could be used to train artificial intelligence for application in classifying osteogenesis imperfecta.