The main function of the ureteral stent is to maintain the urine flow inside the body. Since the majority of commercial stents are composed of non-biodegradable polymer, patients must return to the hospital in order to have the stent removed. However, some patients fail to remember that they have a stent inside of them and only revisit the doctor when they have complications of the forgotten stents. A biodegradable ureteral stent is a key for these problems. Poly (ɛ-caprolactone) (PCL) has been used to combine with other polymers to create biodegradable stents. In this study, different concentrations of PCL will be investigated to examine the effect of the morphological and mechanical properties of PCL electrospun before fabricating a biodegradable ureteral stent. Dissolving PCL in absolute Acetone with different ratios: 15%, 20%, and 25%. After that, an Electrospinning Pilot machine is used to fabricate ureteral stents. The morphology of these stents is then tested by Scanning Electron Microscope (SEM) and the mechanical properties, including tensile and compressive tests are evaluated by Texture Analyzer. Electrospun PCL 25% stents show a porous structure with even and micro-scale fiber along its physical properties are outstanding when compared to PCL 20% and PCL 15%. The porous structure of PCL 25% stent is expected to increase the flow of urine through the stents, and this ability can be improved by combining it with another hydrophilic polymer. The excellent mechanical properties of PCL 25% proved that it could be a good candidate to fabricate biodegradable ureteral stents.

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Investigation Effects of Poly(ɛ-caprolactone) (PCL) Concentration on the Morphological and Mechanical Properties of the Ureteral Stent by Electrospinning Method

  • Tri Cao Duong,
  • Khoa Ngoc-Khanh Tran,
  • Mai-Phuong Tran,
  • Hoan Ngoc Doan,
  • Thi-Hiep Nguyen

摘要

The main function of the ureteral stent is to maintain the urine flow inside the body. Since the majority of commercial stents are composed of non-biodegradable polymer, patients must return to the hospital in order to have the stent removed. However, some patients fail to remember that they have a stent inside of them and only revisit the doctor when they have complications of the forgotten stents. A biodegradable ureteral stent is a key for these problems. Poly (ɛ-caprolactone) (PCL) has been used to combine with other polymers to create biodegradable stents. In this study, different concentrations of PCL will be investigated to examine the effect of the morphological and mechanical properties of PCL electrospun before fabricating a biodegradable ureteral stent. Dissolving PCL in absolute Acetone with different ratios: 15%, 20%, and 25%. After that, an Electrospinning Pilot machine is used to fabricate ureteral stents. The morphology of these stents is then tested by Scanning Electron Microscope (SEM) and the mechanical properties, including tensile and compressive tests are evaluated by Texture Analyzer. Electrospun PCL 25% stents show a porous structure with even and micro-scale fiber along its physical properties are outstanding when compared to PCL 20% and PCL 15%. The porous structure of PCL 25% stent is expected to increase the flow of urine through the stents, and this ability can be improved by combining it with another hydrophilic polymer. The excellent mechanical properties of PCL 25% proved that it could be a good candidate to fabricate biodegradable ureteral stents.