Impact of Nanoclay on the Characterization of Carboxymethyl Cellulose for Biomedical Application
摘要
The hydrogel based on carboxymethyl cellulose and oxidized xanthan gum via acyl hydrazone bonds demonstrates the potential for scaffold fabrication used in tissue regeneration due to its biodegradability, rapid gelation time, injectability, self-healing properties, and biocompatibility. However, its application in the field of 3D printing is limited by its low printability. This study enhances the printability and mechanical properties of the hydrogel base by incorporating different concentrations of LAP, which is known for its aqueous stability and shear-thinning behavior. The hydrogel samples were characterized by rheological properties, mechanical properties, and printability. Rheological analysis revealed that in the presence of LAP, hydrogel exhibited remarkable characteristics, including high storage modulus, excellent shear-thinning capabilities, and rapid recovery abilities increasing the printability. Moreover, the compressive stress of the hydrogel improved with higher Young’s modulus and increased compressive strength. In conclusion, this approach successfully enhanced the mechanical strength and printability of the hydrogel while maintaining its in vitro biocompatibility.