When developing innovative medical devices intended for clinical use, it’s crucial to consider ASTM standards and ISO Norms early in the research phase. For instance, in scaffold guided breast tissue engineering, we use additively manufactured bioresorbable breast scaffolds filled with autologous fat grafts. These scaffolds act as a bioreactor, supporting the regeneration of soft tissue while dissolving over time, resulting in a tissue-engineered construct of regenerated soft tissue. In this study, we aim to biomechanically evaluate 3D-printed breast scaffolds. Based on previous research, we identified Thermoplastic Polyurethane (TPU) with a 6% infill pattern as a good model material due to its tactile sensation, which surpassed that of silicone implants. A major challenge is achieving compressive strength comparable to glandular tissue while maintaining local mechanical performance over a period of at least 3 months. To address this, we printed multiple TPU scaffolds with the same gyroid design and 94 percent porosity but with different print parameters, adhering to ASTM and ISO standards for compressive testing. The findings show that the mechanical properties of a single TPU scaffold design vary depending on the print parameters. Additionally, we concluded that TPU is highly suitable as a benchmark material for soft tissue implants, paving the way for promising biomechanical evaluations under simulated in vivo conditions.