A rapidly increasing number of digital technologies have emerged with the aim of improving public health. To assess these technologies, a framework is needed that incorporates a public health perspective and takes the complexity of the technology, the context in which it operates, and its implementation into account. Existing frameworks focus on health technologies, public health, or digital technologies. A framework for digital public health that supports developers, evaluators, policymakers, and researchers in systematically developing and evaluating digital public health interventions is missing. We combined a scoping review of existing public health and digital health frameworks together with a consensus meeting with multidisciplinary experts. The outcome was a framework (DigiPHrame) that consists of 182 questions, structured by 12 domains: (1) Health Condition and Current Public Health Interventions, (2) Technical Aspects, (3) Usability, (4) Infrastructure and Organization, (5) Implementation, (6) Intended & Unintended Health-related Effects, (7) Social, Cultural, and Intersectional Aspects, (8) Ethics, (9) Legal and Regulatory, (10) Data Security and Data Protection, (11) Cost and Economics, and (12) Sustainability. Potential users can apply these questions to any digital public health intervention they want to develop and assess. The framework is a living framework that will be constantly revised.