Essential Public Health Operation (EPHOEPHOEssential Health Operation) 8 requires the assurance of sustainable financing to provide efficient, effective, and responsive services. Pursuing this purpose requires evidence on how a digital public health (DiPHDiPH) intervention impacts health, the environment, and scarce public health resources. Health economic evaluation provides a set of standards to generate this evidence. Based on the Consolidated Health Economic Evaluation Reporting Standards (CHEERSCHEERSConsolidated Health Economic Evaluation Reporting Standards), this chapter discusses points to consider when evaluating (preventive) DiPH interventions. Specific issues arise, for example, from rapid technological change and the potential for long-term effects beyond the technological life cycle of single interventions. Also, which benefits and harms are to be considered in the economic evaluation depends on the decision maker, and there can be large differences between the decision makers who may acquire DiPH technologies (e.g., private households, health systems, other public payers, and companies). As interventions may have an intersectoral impact, a broader perspective may be necessary. There is also a growing need to account for the planetary boundaries of ecologically sustainable healthcare and public health. These issues can influence the results of an economic evaluation. Therefore it is particularly important for those making decisions on DiPH interventions to reflect on their assumptions and justify which areas may be affected beyond health.