Digital public health (DiPH) interventions have been used to achieve public health disease prevention goals. As a practical example, we describe GetCheckedOnline, a publicly funded web-based testing service for sexually transmitted and blood-borne infections (STBBI) in British Columbia, Canada. This service has gained increasing relevance, especially among people experiencing marginalization who bear a disproportionate burden of STBBIs. It continues to contribute to the secondary and tertiary disease prevention of STBBIs by facilitating early diagnoses and treatment of infections, thereby disrupting their community transmission. In this chapter, we highlight the importance of applying the fundamental public health principle of health equity across the life cycle of DiPH interventions and suggest that a focus on health equity inevitably ensures the achievement of overarching disease prevention goals. We reflect on practical considerations for health equity across various phases of the planning and development, implementation, scale-up, adaptation, sustainment, and maintenance of these DiPH interventions. Further, we demonstrate the central and complementary roles that human-centered design and embedded research and evaluation play in prioritizing health equity across the phases of DiPH interventions. We also highlight key challenges encountered when implementing DiPH interventions that focus on health equity.