This chapter addresses the evolution from global health to public health and back to global public health, as well as delving into the establishment of digital public health, where globalization has played a critical role. We examine a set of examples of global application of digital public health from both Europe and Africa (Angola, Cape Verde, and São Tomé and Principe) contexts. This includes case studies of collaborations comprising several institutions leveraging their different skills and expertise, fully encompassing the concept of global public health. Design science is presented as a relevant scientific approach to support the implementation of digital public health, and a specific framework is provided to relate concrete public health functions with digital public health development opportunities. This can also be used as an agenda for research in global digital public health. In conclusion, a set of global digital public health challenges are summarised. It is argued that capacity building will play a role as public health professionals need to understand how to leverage digital health to bridge the gap with other areas of health. Digital public health could establish a new global and environmental health paradigm within the next ten years, paving the way to digital planetary health.