This chapter addresses the vulnerabilities of supply chains, with a particular focus on those involving electronic hardware embedded in modern cyber-physical systems. It begins by identifying key factors that enable resilience and explains the roles of various actors within the supply chain. The chapter discusses metrics for characterizing cyber resilience and provides a comprehensive review of research on emerging topics related to supply chain resilience. It emphasizes the importance of understanding and mitigating risks associated with supply chain disruptions related to operating conditions and environments, material shortages, counterfeit components, and other stressors. By incorporating a resilience-based perspective, the chapter highlights the need for strategies that go beyond traditional risk assessment to ensure the robustness and adaptability of supply chains. Future research directions include the development of quantitative models, decision-making approaches, and integrated case studies to enhance the cyber resilience of supply chains. The chapter also explores the implications of weather extremes on supply chains, suggesting how discrete event simulation could quantify the effects of related stressors and evaluate mitigation strategies. This approach aims to provide valuable tools for supply chain managers to assess and mitigate a wide array of risks, ensuring resilient operations in the face of global challenges.