Human resource management plays a fundamental role in organizations and can be seen as a strategic programProgram or a more humanistic field of studyField of study. In the current context, marked by disruption and the VUCA worldVUCA world (volatility, uncertainty, complexity, and ambiguity), HRMHuman Resource Management (HRM) faces increasing challenges. The Covid-19 pandemicCOVID-19 pandemic has accelerated changesChange in workWork, making so-called “wicked problems” more evident, that is, complex issues with no single solution. The CRANET databaseCranet database provides insights into HRMHuman Resource Management (HRM) practices at a global level, contributing to adaptation to new realities. Furthermore, technological transformation continuesContinuity to reshape the relationship between workWork and talent management. StakeholderStakeholder HRMHuman Resource Management (HRM) is gaining relevance in academiaAcademia, highlighting the need to align organizational practices with social and scientific expectations. With this dynamic scenario, HRMHuman Resource Management (HRM) must balance efficiency and well-being, adopting innovative approaches to managing people in times of constant changeChange. The challenge we set ourselves with this chapter is to know whether, in disruptive times, such as the ones we are living in, we need toRethink HRM rethink HRMHuman Resource Management (HRM).