Digital games have emerged as powerful tools in healthcare, leveraging serious games, simulations, and VR/AR technologies to enhance medical education, patient care, and therapeutic interventions. Simulation-based games provide risk-free, immersive environments for healthcare professionals to practice critical procedures and decision-making, improving skills and confidence cost-effectively. In patient care, transformational games and VR/AR applications support rehabilitation, chronic disease management, and mental health through gamified feedback, pain distraction, and controlled therapeutic experiences. This chapter explores the role of games and their multiple possible uses in health care.