Quaternary concrete mixes were casted using three supplementary cementitious materials (SCMs) such as fly ash (FA), ground granulated blast furnace slag (GGBS), and silica fume (SF) in this study. The aim of this study is to improve the mechanical characteristics and sustainability of concrete by replacing some of the ordinary Portland cement (OPC) with these SCMs. It was observed that the compressive strength of various mix amounts at 7, 28, and 56 days. At 56 days, the mixture containing 50% OPC, 30% FA, 19% GGBS, and 1% SF showed amaximum compressive strength of 48.62 MPa. Furthermore, the 40% OPC, 35% FA, 23% GGBS, and 2% SF combination produced better long-term strength. The solid pozzolanic activity of FA was validated by chemical analysis, which added to its increased strength and durability. Additionally, the study identified no evidence of a substantial relationship between specific gravity and setting times. In addition to enhancing the mechanical qualities, the addition of these SCMs helped to lower the cement content, which supported sustainable building techniques. The results of this study highlight the possibility of utilising GGBS, SF, and FA to create more durable and sustainable concrete, which could have an impact on reducing energy and CO2 emissions in the building sector. To evaluate these combinations’ long-term performance in varied environmental situations, additional study is recommended.