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The calculation of the sample size in clinical trials requires the specification of the treatment effect for which the study is powered for. This treatment effect must be a realistic projection of the treatment’s efficacy in order to avoid an underpowered study.

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Adaptive Group Sequential Tests

  • 章节

  • 发表日期：

    2025年

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  • Gernot Wassmer,
  • Werner Brannath

摘要

The calculation of the sample size in clinical trials requires the specification of the treatment effect for which the study is powered for. This treatment effect must be a realistic projection of the treatment’s efficacy in order to avoid an underpowered study.