This chapter reviews the major components of the resilience-enhancing stress model (RESM). It emphasizes the roots of the evidence-based foundation of the RESM and the rationale for its overarching person–environment perspective. It also provides a summary of the model’s assumptions about human behavior as well as corresponding terms, practice skills, and strategies. The purpose is to highlight the key elements of the RESM and describe how they have been augmented over time to further meet the needs of social work practitioners. Attention is given to the ways in which elaboration of the model has led to a more proactive resilience-enhancing, anti-oppressive approach to the social work helping process. In addition, a practice example explores the critical skills necessary to ameliorate people’s stress following discriminatory adverse events. Text review questions appear at the end of the chapter.