This chapter explains vital elements in the salutogenic model of health and how these fit into the inner core of health promotion expressed in the Ottawa Charter for Health Promotion. Salutogenesis, is here considered as a theory, a life orientation and as the sense of coherence. In line with the salutogenic theory, health is described as a process in an ease/dis-ease continuum, defined as the movement towards the health end (ease). The generalized and specific resistance resources, defined in the chapter, are internal and external factors giving the prerequisites for developing a strong sense of coherence (SOC). The role of culture is essential in the salutogenic theory, here discussed based on previous research. Salutogenesis is much more than the measurement of SOC, it is seen as an umbrella concept, consisting of many different theoretical concepts and theories. Resilience and empowerment, both concepts familiar to many, are described more in detail. When lecturing Antonovsky always ended by saying: think salutogenically and act salutogenically. Therefore, this chapter ends with a question: what does it mean to be salutogenic, to think salutogenically and act salutogenically? This needs to be further explored. Continuous research is needed to answer the salutogenic question: “What creates health?”