An immense challenge in trace amounts of heavy metal ions involves the identification of electrochemical techniques and devices that possess low detection thresholds, user-friendly, and enable expedited analyses. Efforts to mitigate heavy metal pollution include implementing stricter regulations on industrial discharge, improving waste management practices, and remediation efforts to clean up contaminated sites. Additionally, there’s a growing emphasis on green technologies and sustainable practices to minimize heavy metal ion pollution at its source. The fact that heavy metals like lead (Pb), cadmium (Cd), and mercury (Hg) are not biodegradable gives rise to significant human health concerns. Therefore, there is a need for the development of cost-effective, sensitive, and rapid detection methods for these metals. This chapter presents a major contribution of the electrochemical detection of metals using cyclodextrins-based electrochemical sensing platforms in the previous eras. The cyclodextrin-based electrochemical sensors are introduced after a brief review of the general characteristics of cyclodextrins and their capacity to form inclusion complexes. This comprises cyclodextrins combined with a variety of nanostructured materials (carbon nanotubes, aptamers, and enzymes, conducting polymers, reduced graphene oxide, and electropolymerized cyclodextrin films). The use of these substances in biosensors, chiral recognition agents, and electrochemical environmental pollutant detection of heavy metal ions are discussed. This chapter particularly emphasizes the advantages and limitations of these approaches to the last Water Frame Directive devoted to the Environmental Quality Standards for heavy metals. Recent trends in trace metal speciation as well as the realm of electrochemical sensors and electroanalytical techniques over the previous decades, are discussed.