The Mediterranean Sea is connected with the Red Sea through the Suez Canal. Traditionally, it was a sea passage for internal European trade and imports from Africa and Asia. It is a route where there is a need to ensure stability and avoid any activities that could damage maritime security or bring danger to the lives of individuals. The Mediterranean Sea doesn't currently sustain a realistic threat regarding modern-day piracy. Different considerations can be made regarding the Suez Channel and the Red Sea area. Even if their waters constitute one of the most critical maritime routes enabling global trade, they also present enormous opportunities for development and prosperity in the region. However, increasing regional instability, conflict, piracy, and transnational organized crime endanger the freedom of navigation of vessels transiting through those waters and limit investment into port infrastructure and maritime commerce, according to the International Maritime Organisation (IMO). After an analysis of the risks of the areas in subject, this Chapter explores the main initiatives undertaken at the international level to face them.