The maritime industry is enormous and high-risk-prone. It is one of the largest on the planet earth, and ensuring operations at sea continue safely takes determined effort by states. The collaborative efforts by the Navy of the African states have not yielded the expected results, hence the increase in the number of marine security threats such as piracy, armed robbery, smuggling, kidnapping, and terrorist activities in the continent. This chapter problematizes marine security and administration in Africa and interrogates conceptual issues and theoretical approaches to dealing with marine security threats in the continent. Contributing to the state-of-the-art and academic understanding of marine security in Africa, it seeks to elucidate the undercurrents of marine security in the continent and examine the phenomenon's effects on marine administration, trade, and commerce. Contextualizing the discussion within the cooperative theoretical framework, a critical requirement for an effective marine security regime is the need for a framework of ocean regionalism in Africa. Drawing on desktop design, the discussion is complemented by a review of the literature on marine security threats in the Gulf of Guinea and other marine regimes in the continent.