Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinus mucosa [1]. CRS can be challenging to manage, especially because endoscopic sinus surgery does not address the underlying pathophysiology [2]. Corticosteroids play a key role in the treatment paradigm and are crucial to successful postoperative outcomes. Oral corticosteroids, while beneficial, have undesirable systemic risks and side effects such as weight gain, hyperglycemia, osteoporosis, cataracts, mood changes, suppression of the hypothalamic-pituitary-adrenal axis, and even aseptic necrosis of the joint [3]. Therefore, topical corticosteroid administration to the paranasal sinuses is integral to long-term disease management and successful outcomes. Multiple methods exist for topical corticosteroid administration which vary from corticosteroid nasal drops, corticosteroid nasal sprays, corticosteroid nasal irrigations, nebulization, and steroid eluting stents [4]. Some of these methods can have limitations due to dependence on technique of administration, compliance, and access to therapy [5, 6].

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Steroid Eluting-Implants

  • Firas Sbeih,
  • Jonathan Tyes,
  • Troy Woodard

摘要

Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinus mucosa [1]. CRS can be challenging to manage, especially because endoscopic sinus surgery does not address the underlying pathophysiology [2]. Corticosteroids play a key role in the treatment paradigm and are crucial to successful postoperative outcomes. Oral corticosteroids, while beneficial, have undesirable systemic risks and side effects such as weight gain, hyperglycemia, osteoporosis, cataracts, mood changes, suppression of the hypothalamic-pituitary-adrenal axis, and even aseptic necrosis of the joint [3]. Therefore, topical corticosteroid administration to the paranasal sinuses is integral to long-term disease management and successful outcomes. Multiple methods exist for topical corticosteroid administration which vary from corticosteroid nasal drops, corticosteroid nasal sprays, corticosteroid nasal irrigations, nebulization, and steroid eluting stents [4]. Some of these methods can have limitations due to dependence on technique of administration, compliance, and access to therapy [5, 6].