While self-compassion is increasingly established as holding benefits for the individual, the possibility that it may enhance other-focused care has received considerably less attention. This chapter critically considers this question in the applied domain of healthcare. In considering this question, empirical work linking self-compassion to self- and other-focused outcomes is summarized and combined to inform a discussion of the pathways by which self-compassion is thought to “work.” Insights from these literatures are then combined with self-regulation theory (Baumeister & Heatherton, Psychological Inquiry 7, 1–15, 1996), to frame a discussion of the possible pathways linking self-compassion to other-focused care. While additional empirical work is clearly needed, a model suggesting that a combination of general and compassion-specific pathways likely link self-compassion to enhanced other-focused care in health settings is proposed. Despite design limitations and ongoing measurement challenges, self-compassion may be uniquely suited to the challenges of healthcare settings, including the need to sustain care for other people.