Ultrasound is a safe and fast modality that uses sound waves to produce real-time images across various clinical applications, such as obstetrics, gynecology, and cardiac and abdominal imaging. Its strong safety record has led to widespread adoption and expanding applications in clinical decision-making. While no proven deleterious effects are associated with ultrasound, careful management is essential, particularly in obstetric and neonatal imaging, as new techniques are introduced. In addition, advancements in ultrasound technology and relaxed regulatory restrictions have enabled high-power diagnostic exams that enhance diagnostic capabilities but may pose risks of mechanical and thermal effects. Ongoing oversight from regulatory and professional organizational helps maintain ultrasound’s exceptional safety record by providing a framework for responsible use. This chapter reviews ultrasound technique, its clinical applications, and associated quality and patient safety considerations. We also discuss relevant regulatory guidelines and standards.