Radiography is the most commonly used radiological imaging modality, offering quick and detailed views for clinical diagnosis. This chapter provides an overview of patient safety and quality concerns in radiography, beginning with the fundamental principles of digital radiographic devices. It extensively discusses patient safety, including common technologies and techniques to minimize patient radiation exposure while maintaining diagnostic quality. The chapter also highlights the importance of quality control and image quality, along with tools available to help radiology staff and departments achieve consistent, high-quality images. Current regulatory and industry initiatives focused on enhancing quality and patient safety in radiographic imaging are also discussed.