A significant portion of the deaf-mute community experiences barriers in accessing education, healthcare, and employment opportunities due to communication constraints. The Indian Sign Language (ISL) Interpreter is a compact, user-friendly device that bridges the communication barrier between deaf-mutes and normal persons. The device converts hand and facial cues integrated gestures into text and audio for normal people to understand. Unlike a universal sign language, Indian Sign Language has its distinct syntax, grammar, multimodal integration of facial cues and hand gestures, and vocabulary tailored to India’s cultural and linguistic diversity. Implementing ISL through the Portable Interpreter Device ensures a culturally relevant and effective means of communication for the Indian deaf-mute community. The dataset for training and validation has been custom-created by four independent signers. Hand and facial cues integrated self-made dataset, using computer vision techniques and machine learning tools, help in the real-time sentence-level conversion of dynamic ISL gestures into text and audio. An accuracy of 97 % ensures the efficient sentence-level conversion of ISL gestures into text and audio. ...