Safe, secure, and timely goods transport is the backbone of the global economy. Commercial vehicles carry an array of goods, necessitating diverse vehicle bodies and varying demands on securing cargo. Cargo securing ensures that cargo movement or, even worse, the falling out of cargo from the vehicle is avoided. Therefore, cargo security is relevant for the safety of both the goods and traffic. It is anchored in norms and guidelines, which help standardize specifications for vehicle body manufacturers, makers of securing equipment, and fleet operators. Typically, these specifications are given in the form of lateral and longitudinal accelerations in pre-defined driving maneuvers. Since accidents in which a commercial vehicle has lost cargo is not uncommon, the authors believe that possibly higher accelerations are encountered in real driving than those specified by today’s norms and regulations. In this project “CargoSec” funded by the German Federal government, different classes of vehicle were tested under varying load conditions on different road surfaces in driving maneuvers, representative of real world driving. It was determined that N1 and N2 classes of commercial vehicles produce acceleration values much beyond those set by norms and regulations. The authors have therefore proposed changes to relevant norms and guidelines.