Primary care’s approach to caring for patients is well suited for serving patients with a multitude of health needs, whether it be medical, behavioral, or social. In caring for patients with substance use disorders, the multifaceted approach is key to support and help patients on their health journey. Primary care teams have the potential to work in collaboration with other sectors (for example: social work, behavioral health, and consulting medical specialties) to properly and holistically care for people with substance use disorders. When caring for patients with substance use disorders, solid understandings about the pathophysiology of addiction, barriers to healthcare that includes stigma, evidence-based medical treatment, the importance of working within a collaborative care model, and the multifaceted components to substance use disorders comprise a skillset that harmonizes breadth of treatment modalities, fosters trust and collaboration, and leaves plenty of space for healing. Many factors in the United States needed to come together, and in some cases, be overcome, for people with substance use disorders to begin to attain proper treatment—and more is needed. Insurance coverage and collaborative care teams or integrated health models are two aspects that have allowed treatment for substance use disorders to move forward in the realm of primary care. More is needed to ensure proper medical and behavioral training, caring for, and treatment for people with substance use disorders.