Relationship-centered practices possess the qualities of being alive and connected to the world, as well as being a present and conscious being. It allows a patient’s experience to be felt, heard, and captivated by both the patient and the clinician. These practices provide an authentic connection within the therapeutic relationship and allow genuine rapport building and active listening, as well as the patient experiencing a sense of acceptance, love, and freedom. Within the following chapter, this author will review various relationship-centered practices such as person-centered therapy (PCT) developed by Carl Rogers, motivational interviewing (MI) developed by William R. Miller, acceptance and commitment therapy (ACT) developed by Steven C. Hays, and working in co-occurring care. The chapter will outline three relationship-centered practices and how each can be applied in co-occurring care across disciplines.